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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are often focused on the practical aspects of study design, such as the recruitment process and 프라그마틱 무료체험 메타 무료 (stay with me) consent in adherence, as well as the use of standard equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which utilized various investigators and had participants from various geographical areas. This type of heterogeneity is required for pragmatic trials to be able to prove their validity and also reduces bias in the results. Too much heterogeneity, however, can cause problems with the design of the trial.

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The aim of pragmatic trials is to simulate real-life scenarios and gain maximum validity externally. They are typically ordered by policymakers and practitioners to help inform their decisions. They also provide a useful method to determine the causal relationship between the intervention and its effects. However, they shouldn’t be used to substitute for explanation studies.

The concept of pragmatism is controversial, and there are questions about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested an distinction between explanation-based studies, which support a physiological hypothesis or clinical hypothesis, and pragmatic trials, which inform the decision-making process for policy and practice. They also proposed a framework for pragmatic trials, dubbed PRECIS.2 This tool was designed to define the characteristics of a pragmatic trial which includes the recruitment process, the design and delivery of the intervention, and follow-up.

There is an encouraging trend in the number of pragmatic trials that have been published. A recent Medline search using the terms pragmatic and naturalistic, restricted to controlled trials randomized to control (RCTs), yielded 34 articles, which are shown in red in Figure 2. This is an indication that the health sciences community is becoming more acquaint to the subject of pragmatism. It is important to note that the majority of these trials were conducted in primary care settings.