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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are often characterized by a focus on practical aspects of the study design, including the recruitment process and consent, adherence, and the use of commonly available equipment.
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A pragmatic trial that uses various investigators and 라이브 카지노 participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity which is vital for a pragmatic trial to be valid and reduce bias in results is also essential. Too much heterogeneity, however can result in problems with the trial design.
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The aim of pragmatic trials is to mimic real-life situations and achieve the highest level of validity externally. They are usually commissioned by policy makers and practitioners to inform their decision making. They can be used to determine the causality of an intervention and its results. However, they shouldn’t be used as a substitute for the use of explanation trials.
The pragmatism idea is controversial and there are concerns about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanation studies, which prove a physiological hypothesis or clinical hypothesis, as well as pragmatic trials, 프라그마틱 슬롯 추천 that inform the practice and policy decision-making. They also suggested an approach to pragmatic trials, dubbed PRECIS.2 This tool sought to define the features of a pragmatic study, including recruitment, design and delivery of the intervention, and monitoring.
There is a growing trend in the number of pragmatic trials that have been published. A recent Medline search using the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This is an indication that the health science community is becoming more acquaint to the subject of pragmatism. It is important to keep in mind that the majority of studies were conducted in primary care settings.